包霞珍

【发布单位: 发布时间:2022-01-13 浏览量:5536

姓名:包霞珍

职称:副教授/硕士研究生导师

学科专业:有机化学

Email: baoxiazhen@nwnu.edu.cn

地址:437必赢会员中心新校区综合实验楼E-422


【个人简介】

包霞珍,博士,副教授硕士生导师20136于437必赢会员中心取得理学学士学位;201812月于兰州大学功能有机分子化学国家重点实验室取得博士学位;20197月加入437必赢会员中心从事博士后研究20217月出站并留校工作。

【研究项目】

国家自然科学基金地区项目(32260223),2023-2026,主持

甘肃省青年科技基金计划(21JR7RA148),2021-2024,主持

437必赢会员中心青年教师能力提升计划(NWNU-LKQN2021-12),2021主持

国家自然科学基金面上项目(22174111),2022-2025,参与

【研究兴趣】

1. 以细胞命运调控为主线的分子探针设计、合成及应用研究

2. 基于癌细胞的氧化还原特征设计促氧化抗癌前药并探究其抗癌机制

教学

《有机化学》、《有机化学实验》和《基础化学实验》等

【代表性论文】

1. Bao, X.*; Cao, X.; Ai, K.; Cui, Y.; Han, Z.; Zhou, B.*; Huo, C.*, A dual-reaction-site and dual-channel fluorescent-on probe for selectively monitoring mitochondrial glutathione. Sens. Actuators B: Chem. 2023, 382, 133563.

2. Bao, X.*; Ai, K.; Cao, X.; Chen, D.; Zhou, B.*; Huo, C.*, A dual-site and dual-turn-on fluorescence probe for imaging mitochondrial HClO and SO2. Dyes Pigm. 2022, 197, 109928.

3. Bao, X.*; Cao, X.; Yuan, Y.; Zhou, B.*; Huo, C.*, A water-soluble, highly sensitive and ultrafast fluorescence probe for imaging of mitochondrial hypochlorous acid. Sens. Actuators B: Chem. 2021, 344, 130210.

4. Bao, X.*; Cao, X; Yuan, Y.; Zhou, B.*; Huo, C*, Ultrafast Detection of Sulfur Dioxide Derivatives by a Distinctive “Dual-Positive-Ion” Platform that Features a Doubly Activated but Irreversible Michael Addition Site. J. Agric. Food Chem. 2021, 69, 4903-4910.

5. Bao, X.; Jiang, W.; Liang, J.; Huo, C.*, One-Electron Oxidative Dehydrogenative Annulation and Cyclization Reactions. Org. Chem. Front. 2020, 7, 2107-2144.

6. Bao, X.-Z.; Wang, Q.; Ren, X.-R.; Dai, F.; Zhou, B.*, A hydrogen peroxide-activated Cu(II) pro-ionophore strategy for modifying naphthazarin as a promising anticancer agent with high selectivity for generating ROS in HepG2 cells over in L02 cells. Free Radic. Biol. Med. 2020, 152, 597-608.

7. Bao, X.; Li, J.; Jiang, W.; Huo, C.*, Radical-Mediated Difunctionalization of Styrenes. Synthesis 2019, 51, 4507-4530.

8. Bao, X.-Z.; Dai, F.; Wang, Q.; Jin, X.-L.; Zhou, B.*, Developing glutathione-activated catechol-type diphenylpolyenes as small molecule-basedand mitochondria-targeted prooxidative anticancer theranostic prodrugs. Free Radic. Biol. Med. 2019, 134, 406-418.

9. Bao, X.-Z.; Dai, F.; Li, X.-R.; Zhou, B.*, Targeting redox vulnerability of cancer cells by prooxidative intervention of a glutathione-activated Cu(II) pro-ionophore: Hitting three birds with one stone. Free Radic. Biol. Med. 2018, 124, 342-352.

【专利】

1. 包霞珍;霍聪德;袁勇,一种苯并吡喃鎓-吩噻嗪衍生物及其制备方法和应用,专利号:ZL 2020 1 1373909.3,授权公告号:CN 112358475 B

2. 包霞珍;霍聪德;袁勇,一种甲基喹啉-苯并吡喃鎓衍生物及其制备方法与应用,专利号:ZL 2020 1 1377417.1,授权公告号:CN 112390790 B



联系方式

学院办公室:0931-7970806

本科教务办公室:0931-7970144

研究生教务办公室:0931-7971851

团委办公室:0931-7971535

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